Can I Take Cetirizine Hydrochloride and Fexofenadine Hydrochloride Together

Contents

• What is fexofenadine
  • • • How long does information technology take for fexofenadine to work?
      • Can I drink alcohol with fexofenadine?
      • Is there any food or drink I need to avert?
      • What else should I avoid?
      • What's the difference between fexofenadine and other antihistamines?
      • What's the deviation between fexofenadine and other non-drowsy antihistamines?
      • How long should I take fexofenadine for?
      • Is it safe to have fexofenadine for a long time?
      • Can I bulldoze or ride a wheel with fexofenadine?
      • Does fexofenadine crusade weight gain?
      • Tin I take fexofenadine with painkillers?
      • Can I take more than than one antihistamine together?
      • Can I take fexofenadine with other hay fever treatments?
      • Can I take fexofenadine at higher doses than on the packet?
      • Can lifestyle changes relieve hay fever?
  • Who can and can't take fexofenadine
    • Fexofenadine Drug Interactions
    • Before taking fexofenadine – Precautions
    • Pregnancy and Breastfeeding
      • I just plant out I am meaning. Should I stop taking fexofenadine?
      • I am significant. Can use of fexofenadine during pregnancy cause birth defects?
      • Can fexofenadine crusade a miscarriage?
      • Tin use of fexofenadine cause other pregnancy complications?
      • Volition fexofenadine impact my fertility?
      • Will fexofenadine affect my contraception?
      • What if the father of the baby takes fexofenadine?
      • Fexofenadine and breastfeeding
  • Fexofenadine vs Cetirizine
  • Fexofenadine vs Loratadine
  • What is fexofenadine used for
  • Fexofenadine dose
    • • Usual Adult Dose for Allergic Rhinitis
      • Usual Developed Dose for Urticaria
      • Usual Pediatric Dose for Allergic Rhinitis
      • Usual Pediatric Dose for Urticaria
      • Renal Dose Adjustments
      • Liver Dose Adjustments
      • Dialysis
    • How and when to accept fexofenadine
      • How should fexofenadine be used?
      • How much should I have?
      • How to take fexofenadine
      • When to take fexofenadine
      • What if I forget to have information technology?
      • What if I take too much fexofenadine?
  • Fexofenadine side effects
    • Common side effects
    • Serious side furnishings
    • How to cope with side effects
    • Man Toxicity Reports
  • Fexofenadine overdose

What is fexofenadine

Fexofenadine is a non-drowsy antihistamine that is used to relieve the symptoms of allergies, hay fever (seasonal allergic rhinitis) and hives of the skin (chronic idiopathic urticaria). Fexofenadine is a second generation antihistamine that is much less likely to brand you lot feel sleepy than some other antihistamines. Fexofenadine is a histamine [H1] receptor blocker, that works by blocking the action of histamine, a substance in the torso that causes allergic symptoms. When you come into contact with something you have an allergy to, such as pollen, animal hair or fur, house grit or insect bites, your trunk produces a chemical chosen histamine. Histamine is a chemical that'southward released by Mast cells in your body when an allergen is encountered that can produce symptoms of sneezing, hives, itching, watery optics, and runny nose, also known as hypersensitivity reactions. Usually histamine is a useful substance simply in an allergic reaction information technology causes unpleasant symptoms including itchy, watery eyes, running or blocked nose, sneezing and skin rashes. Fexofenadine blocks the effects of histamine and then reduces these symptoms.

Fexofenadine is used to care for hay fever (seasonal allergic rhinitis), allergic conjunctivitis (ruddy, itchy eye), itchy throat, eczema and hives of the skin (nettle rash or chronic idiopathic urticaria). Fexofenadine is also used for reactions to insect bites and stings and for some nutrient allergies.

Fexofenadine is available is an over-the- counter (OTC) and also on prescription. It comes every bit tablets, meltable tablets, sheathing and liquid suspension

Cardinal facts

• It's usual to take fexofenadine once a day. Children sometimes take it twice a solar day.
• Fexofenadine is classed as a non-drowsy antihistamine, but some people still discover it makes them feel quite sleepy.
• Mutual side effects include headache, feeling sleepy, dry out mouth, feeling sick and dizziness.
• Don't drink grapefruit juice, apple tree juice or orange juice while yous're taking fexofenadine. It might brand y'all more likely to go side effects.
• Information technology's best not to drink booze while yous're taking fexofenadine as it can make you feel sleepy.
• Fexofenadine is also chosen by the brand proper name Telfast, Allegra, Allegra 24 Hour Allergy, Allegra Allergy, Allegra ODT, Aller-Ease, Children'southward Allegra Allergy, Children's Allegra ODT, Allergy Relief (Fexofenadine HCl), Mucinex Allergy, Wal-Fex and Allegra OTC.

How long does it accept for fexofenadine to work?

You should start to experience better within an hour or 2.

Tin I beverage alcohol with fexofenadine?

It'due south all-time not to drink alcohol while you're taking fexofenadine equally it can brand yous feel sleepy.

Is at that place whatsoever food or potable I need to avert?

Don't drink grapefruit juice, orange juice or apple juice while taking fexofenadine. Information technology might make you more likely to have side effects.

Fruit juices tin go far harder for your body to absorb fexofenadine. Do non take fexofenadine with fruit juice (such every bit apple, orange, or grapefruit).

What else should I avert?

Avoid using antacids inside 15 minutes before or afterwards taking a medication that contains fexofenadine. Antacids can make information technology harder for your body to absorb this medication.

Avoid taking any other cold or allergy medicines unless your dr. has told you to.

What's the difference between fexofenadine and other antihistamines?

Fexofenadine is known every bit a non-drowsy antihistamine. That's considering it'due south less likely to brand you feel sleepy than other, so-called 'sedating antihistamines' such as Benadryl or Diphenhydramine.

Most people prefer to take a non-drowsy antihistamine instead of a sedating i. An exception is when you lot desire the medicine to make you lot sleepy, for example if y'all accept itchy skin that'southward keeping you lot awake at night.

What'southward the difference between fexofenadine and other not-drowsy antihistamines?

Other non-drowsy antihistamines like acrivastine, cetirizine (Zyrtec), loratadine (Claritin), desloratadine and levocetirizine seem to work just as well as fexofenadine.

However, fexofenadine seems to be less probable to make you experience sleepy than other non-drowsy antihistamines.

If one non-drowsy antihistamine hasn't worked for you, it's worth trying another one.

How long should I take fexofenadine for?

It depends on why you're taking fexofenadine.

You lot may just need to take information technology equally a one-off dose or for a twenty-four hours or 2, for example if you have a reaction to an insect bite.

You lot may need to have fexofenadine for longer if you're taking it to prevent symptoms – for instance, to stop hay fever when the pollen count is loftier.

Talk to your doctor or pharmacist if you lot're unsure how long you need to take fexofenadine for.

Is information technology safe to take fexofenadine for a long time?

Fexofenadine is unlikely to practise you any impairment if y'all take it for a long time. Withal, it's all-time to take fexofenadine only for equally long as y'all need to.

Tin I drive or ride a wheel with fexofenadine?

Fexofenadine is classed as a non-drowsy antihistamine just it'due south still possible to experience sleepy afterwards taking it.

If you're taking fexofenadine for the commencement time, come across how it makes you feel before driving, cycling or using heavy machinery or tools.

Does fexofenadine crusade weight gain?

Fexofenadine isn't known to cause weight proceeds.

Can I have fexofenadine with painkillers?

Yes, y'all can accept fexofenadine together with acetaminophen (Tylenol) or ibuprofen (Motrin).

Can I accept more than one antihistamine together?

Sometimes doctors recommend that people with a astringent itchy skin rash have 2 dissimilar antihistamines together for a few days.

Also as taking a not-drowsy antihistamine during the day such as fexofenadine, Zyrtec (Cetirizine) or Claritin (Loratadine), your doctor may propose that you take a sedating antihistamine (due east.g. Benadryl) at nighttime time if the crawling is making it difficult to slumber.

Exercise not take 2 antihistamines together unless your physician advises y'all to.

Can I take fexofenadine with other hay fever treatments?

Yes, it's fine to have fexofenadine together with other hay fever treatments, for example steroid nasal sprays (such as Beconase, Rhinacort Aqua and Flixonase Nasules) or eye drops.

Can I have fexofenadine at higher doses than on the package?

Your md might advise yous or your child accept a college dose of fexofenadine (upwardly to iv times the usual dose) for a astringent itchy peel rash or angioedema (swelling underneath the skin).

Taking high doses of fexofenadine isn't suitable for everyone. Speak to your doctor if you don't remember fexofenadine is working for yous.

Can lifestyle changes relieve hay fever?

It volition help if y'all don't spend besides much time outside if the pollen count is high.

Tips for when you're outside:

• Don't cut grass or walk on grass.
• Wear wraparound sunglasses to end pollen getting into your eyes.
• Put Vaseline around your nostrils to help trap pollen.
• Shower and change your clothes after you've been outside to launder off pollen.

Tips for when you're inside:

• Keep windows and doors close as much as possible.
• Vacuum regularly and dust with a damp cloth.
• Don't continue fresh flowers in the house.
• Don't smoke or be around fume equally it makes hay fever symptoms worse.

Who tin and can't have fexofenadine

Fexofenadine tablets can be taken past adults and children aged 6 years and over.

In deciding to apply a medicine, the risks of taking the medicine must be weighed against the good information technology will do. This is a conclusion you and your doctor volition make. For this medicine, the following should be considered.

Fexofenadine isn't recommended for people over 65 years old because there isn't much research on the medicine in this historic period grouping. Talk to your pharmacist or medico if you're over 65 and want to accept fexofenadine. Elderly patients are more likely to take age-related kidney bug, which may require an adjustment in the dose for patients receiving fexofenadine.

Fexofenadine isn't suitable for some people. Tell your doctor or pharmacist if you lot:

• have had an allergic reaction to fexofenadine or any other medicines in the past. Also tell your wellness care professional person if you have whatsoever other types of allergies, such equally to foods, dyes, preservatives, or animals. For not-prescription products, read the label or package ingredients carefully.
• have problems with your liver or kidneys
• have, or have always had, middle problems
• have epilepsy or some other health problem that puts you at risk of seizures
• are booked to accept an allergy test – taking fexofenadine may affect the results, so you might need to stop taking it a few days before the exam

Other Medical Issues

The presence of other medical bug may bear on the utilise of this medicine. Make sure y'all tell your medico if y'all have any other medical problems, especially:

• Kidney disease — Apply with circumspection. The effects may be increased because of slower removal of the medicine from the trunk .
• Phenylketonuria (PKU) — Use with caution. The oral disintegrating tablets comprise phenylalanine .

Pediatric patients

Advisable studies take not been performed on the human relationship of age to the furnishings of fexofenadine in children below 6 months of age. Rubber and efficacy have not been established.

• Do NOT give fexofenadine to a child without medical advice.

Do not give any cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side furnishings.

Fexofenadine Drug Interactions

Tell your doctor or chemist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Some medicines and fexofenadine interfere with each other and increase the chances of yous having side effects. Check with your pharmacist or doctor if yous're taking:

• midodrine, a medicine used to treat low blood pressure
• ketoconazole, a medicine to treat fungal infections
• erythromycin, an antibody
• ritonavir or lopinavir, medicines used to treat HIV infection
• rifampicin, an antibody
• indigestion remedies containing aluminium or magnesium – leave about 2 hours between the times that yous take fexofenadine and your indigestion remedy
• any medicine that makes you drowsy, gives you a dry rima oris, or makes information technology difficult for you to pee. Taking fexofenadine might make these side effects worse.

Using fexofenadine with any of the following medicines is unremarkably not recommended, just may exist required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often yous utilize ane or both of the medicines.

• Eliglustat
• Simeprevir

Using fexofenadine with whatever of the post-obit medicines may crusade an increased risk of certain side effects, but using both drugs may exist the best treatment for you. If both medicines are prescribed together, your md may alter the dose or how often you lot use one or both of the medicines.

• Aluminum Carbonate, Bones
• Aluminum Hydroxide
• Aluminum Phosphate
• Dihydroxyaluminum Aminoacetate
• Dihydroxyaluminum Sodium Carbonate
• Magaldrate
• Magnesium Carbonate
• Magnesium Hydroxide
• Magnesium Oxide
• Magnesium Trisilicate
• St John'southward Wort

Mixing fexofenadine with herbal remedies and supplements

There might be a problem taking some herbal remedies and supplements alongside fexofenadine – especially ones that cause sleepiness, a dry oral fissure or arrive difficult to pee.

Before taking fexofenadine – Precautions

• tell your doctor and pharmacist if you are allergic to fexofenadine, any other medications, or any of the ingredients in fexofenadine tablets or intermission. Ask your pharmacist for a list of the ingredients.
• tell your md and chemist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products yous are taking or plan to take. Be sure to mention either of the post-obit: erythromycin (E.Due east.Southward., E-Mycin, Erythrocin) and ketoconazole (Nizoral). Your doctor may need to change the doses of your medications or monitor you carefully for side furnishings.
• if you are taking an antacid containing aluminum or magnesium (Maalox, Mylanta, others), take the antacid a few hours earlier or after fexofenadine.
• tell your doctor if you have or have ever had kidney disease.
• tell your doc if you are meaning, programme to go significant, or are breast-feeding. If you become pregnant while taking fexofenadine, call your medico.

Pregnancy and Breastfeeding

For safety, tell your pharmacist or doctor if you're trying to become pregnant, are already pregnant or if you're breastfeeding.

Fexofenadine isn't normally recommended during pregnancy.

FDA pregnancy category C:Brute studies have shown an agin effect and there are no adequate studies in meaning women OR no animal studies have been conducted and at that place are no adequate studies in pregnant women.

It is not known whether fexofenadine volition impairment an unborn infant. Tell your doctor if you lot are significant or program to become significant while using this medicine.

A similar antihistamine called Loratadine (Claritin) is usually used first because there'due south more information to say that it's safer.

Talk to your md nigh the benefits and possible harms of taking fexofenadine. It will besides depend on how many weeks meaning you are and the reason you need to take fexofenadine.

I simply establish out I am pregnant. Should I end taking fexofenadine?

You should always talk with your healthcare provider earlier making any changes in your medications. It is important to consider the benefits of treating allergy symptoms and other conditions during pregnancy. Treating allergy symptoms may reduce asthma symptoms and the demand for additional asthma medicines.

In people who took sixty mg of fexofenadine twice a day, information technology could have up to 4 days for all of this medication to leave the body.

I am significant. Tin utilise of fexofenadine during pregnancy cause nascency defects?

And then far, studies on both fexofenadine and Terfenadine [terfenadine changes into fexofenadine in the body, and then information on terfenadine may as well be helpful for predicting the furnishings of fexofenadine on pregnancy and breastfeeding] have not found an increase in birth defects with use of these medicines ¹⁾ , ²⁾ , ³⁾ , ^iv) , ⁵⁾ , ^half-dozen) .

Can fexofenadine cause a miscarriage?

At that place are no studies that have looked at whether fexofenadine tin can increase the chance for a miscarriage.

Can use of fexofenadine cause other pregnancy complications?

No studies have looked at whether fexofenadine could cause other pregnancy complications. A written report on Terfenadine [terfenadine changes into fexofenadine in the trunk, and so information on terfenadine may also exist helpful for predicting the furnishings of fexofenadine on pregnancy and breastfeeding] institute no increase in premature commitment or low birth weight with use during pregnancy.

Will fexofenadine affect my fertility?

There'south no testify that fexofenadine affects male or female person fertility.

Will fexofenadine touch on my contraception?

Fexofenadine doesn't touch any blazon of contraception, including the contraceptive pill and the morning time afterward pill.

What if the father of the baby takes fexofenadine?

There is no evidence that suggests that a human being's fexofenadine utilize would crusade whatever bug during his partner's pregnancy. In general, exposures that fathers take are unlikely to increase risks to a pregnancy.

Fexofenadine and breastfeeding

At that place's not a lot of information on the use of fexofenadine during breastfeeding, and so it'due south best not to take it.

• Fexofenadine during breastfeeding is not recommended.

It's commonly safe to take similar antihistamines called Loratadine (Claritin) and Cetirizine (Zyrtec) while y'all're breastfeeding.

Yet, speak to your doctor before taking whatever antihistamine if your infant was premature, had a low nativity weight or has other health problems.

It is non known if fexofenadine hydrochloride is distributed into breast milk ⁷⁾ . Since there are no adequate and controlled studies to date on the apply of fexofenadine during lactation in humans and considering many drugs are excreted in human milk, the manufacturer states that fexofenadine alone or in stock-still combination with pseudoephedrine hydrochloride should be used with circumspection in nursing women, and a decision should exist made whether to discontinue nursing or the drug, taking into account the importance of the drug to the adult female ^viii) .

Fexofenadine is less likely to cause sleepiness in adults than another antihistamines. For this reason, fexofenadine may exist preferred for breastfeeding over antihistamines that practice crusade sleepiness. Information from Terfenadine [terfenadine changes into fexofenadine in the body, so information on terfenadine may also exist helpful for predicting the effects of fexofenadine on pregnancy and breastfeeding] suggests that the amount of fexofenadine in the breastmilk is pocket-sized. One study estimated that a baby that was breastfed past a mother taking fexofenadine got less than ane% of the female parent's dose ^ix) . This dose would be too low to cause bug for the infant.

When 25 women were asked by telephone how their babies were doing while they were taking terfenadine and breastfeeding, iii mothers said their babies experienced irritability but that they did not need to take the babies to a healthcare provider ¹⁰⁾ . Information technology is not possible to know if their irritability was caused by terfenadine in breastmilk.

It is possible, but not proven, that antihistamines may lower the corporeality of milk a adult female makes. This might be more likely to occur if antihistamines are used in combination with an oral decongestant like pseudoephedrine or phenylephrine, or if used earlier beginning to breastfeed.

Exist sure to talk to your health intendance provider about all your breastfeeding questions.

Fexofenadine vs Cetirizine

Cetirizine or cetirizine hydrochloride (cetirizine HCL) is a not-drowsy antihistamine medicine that relieves the symptoms of allergies by blocking the effects of the chemic histamine in your trunk. Histamine is a chemic that'due south released by Mast cells in your body when an allergen is encountered that tin produce symptoms of sneezing, hives, itching, watery eyes, and runny nose, also known every bit hypersensitivity reactions. Cetirizine is much less likely to make yous feel sleepy than another first generation or older antihistamines. Cetirizine was the first marketed drug from the series of second-generation antihistamines showing both minimal side effects on the central nervous arrangement and a reduced level of cardiotoxicity ^xi) .

When you come into contact with something you're allergic to, such as pollen, creature pilus or fur, business firm dust or insect bites and stings, your body produces a chemic called histamine. Usually histamine is a useful substance but in an allergic reaction it causes unpleasant symptoms including itchy, watery eyes, running or blocked nose, sneezing and skin rashes.

Cetirizine blocks the furnishings of histamine and reduces these symptoms.

Cetirizine starts to work within 30 – 60 minutes after being taken. Yous should start to experience better inside an 60 minutes.

Key facts:

• Information technology's usual to take cetirizine in one case a day. Children sometimes take it twice a day.
• Cetirizine is classed as a non-drowsy antihistamine, simply some people nevertheless find it makes them experience quite sleepy.
• Mutual side effects include headache, dry rima oris, feeling sick, dizziness, tum hurting and diarrhea.
• It's all-time not to drink alcohol while you're taking cetirizine as information technology can brand you feel sleepy.
• Cetirizine is sold under the trade names Benadryl Allergy, Piriteze, Zirtec, Zyrtec, and Reactine.

Cetirizine is available on prescription. Y'all tin too purchase it from pharmacies and supermarkets.

Cetirizine comes as tablets, capsules and as a liquid that you lot swallow.

Despite cetirizine is being marketed equally a non-drowsy antihistamine, it may still impair your thinking or reactions. Be careful if y'all drive or do anything that requires yous to be alert. Drinking booze can increase certain side effects of cetirizine.

Tell your doctor if yous regularly use other medicines that brand you lot sleepy (such every bit other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or feet). They can add together to sleepiness caused by cetirizine. Telephone call your doctor if your symptoms practise not ameliorate, if they get worse, or if y'all also have a fever.

Fexofenadine vs Loratadine

Loratadine is a non-drowsy antihistamine (a second generation antihistamine) medicine that relieves the symptoms of allergies. Loratadine is used to care for hay fever, allergic conjunctivitis (scarlet, itchy eye), eczema and hives. Loratadine is also used for reactions to insect bites and stings and for some food allergies. Loratadine is much less probable to make yous feel sleepy than another antihistamines such as diphenhydramine. About people adopt to take a non-drowsy antihistamine instead of a sedating i. An exception is when yous want the medicine to make you sleepy because you've got itchy pare that'south keeping you awake.

Loratadine is a histamine [H1] receptor blocker, it works by blocking the action of histamine, a substance in the body that causes allergic symptoms. When you come up into contact with something you have an allergy to, such every bit pollen, beast hair or fur, house dust or insect bites, your body produces a chemical chosen histamine. Histamine is a chemical that'due south released by Mast cells in your body when an allergen is encountered that tin can produce symptoms of sneezing, hives, itching, watery optics, and runny nose, too known as hypersensitivity reactions. Usually histamine is a useful substance but in an allergic reaction it causes unpleasant symptoms including itchy, watery optics, running or blocked nose, sneezing and skin rashes. Loratadine blocks the effects of histamine and so reduces these symptoms.

Loratadine is as well available in combination with pseudoephedrine (Sudafed, others). This article simply includes information about the use of loratadine lonely. If you are taking the loratadine and pseudoephedrine combination product, read the information on the package label or ask your doctor or pharmacist for more than data.

Loratadine is bachelor on prescription. You tin can also purchase loratadine from pharmacies and supermarkets.

Loratadine comes equally a syrup (liquid), an firsthand acting and extended release tablet, and a rapidly disintegrating (dissolving) tablet to take by mouth. It is commonly taken once a day with or without food. Follow the directions on the bundle label carefully, and enquire your doctor or chemist to explain whatever function yous do not understand. Take loratadine exactly as directed. Do non take more or less of it or take it more oft than directed on the bundle label or recommended past your doctor. If y'all accept more loratadine than directed, you lot may feel drowsiness.

If you are taking the apace disintegrating tablet, follow the parcel directions to remove the tablet from the blister packet without breaking the tablet. Practise not endeavour to push button the tablet through the foil. After yous remove the tablet from the blister package, immediately place it on your tongue and close your mouth. The tablet will quickly dissolve and can be swallowed with or without water.

Exercise not use loratadine to treat hives that are bruised or blistered, that are an unusual color, or that exercise not crawling. Telephone call your doctor if you accept this type of hives.

Finish taking loratadine and call your doc if your hives do not better during the kickoff 3 days of your treatment or if your hives last longer than 6 weeks. If you do not know the cause of your hives, phone call your doctor.

If you are taking loratadine to care for hives, and you develop any of the following symptoms, get emergency medical help right abroad:

• difficulty swallowing,
• speaking, or breathing;
• swelling in and around the mouth or swelling of the tongue;
• wheezing; drooling;
• dizziness; or loss of consciousness.

These may be symptoms of a life-threatening allergic reaction called anaphylaxis. If your doc suspects that you may experience anaphylaxis with your hives, he may prescribe an epinephrine injector (EpiPen). Do not use loratadine in identify of the epinephrine injector.

Do non use this medication if the safety seal is open up or torn.

Loratadine was evaluated for efficacy and safety in 228 patients with perennial allergic rhinitis. Taken at a dose of ten mg once daily, loratadine was significantly more effective than placebo and comparable to terfenadine, lx mg taken twice daily, in reducing combined symptom scores in this patient population. Efficacy was maintained throughout the 28 day course of treatment ¹²⁾ . The overall incidence of side furnishings with loratadine was low (14%) with few occurrences of sedation (3%) and dry oral fissure (4%).

Cardinal facts

• Information technology'southward usual to have loratadine once a 24-hour interval.
• Loratadine is classed as a non-drowsy antihistamine, merely some people still discover it makes them feel slightly sleepy.
• Children may also have a headache and feel tired or nervous after taking loratadine.
• Information technology'due south best Non to drink alcohol while you're taking loratadine every bit it can brand you lot feel sleepy.
• Loratadine is as well called by the brand names Clarityn Allergy, Clarityn Rapide Allergy, Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetapp ND, ohm Allergy Relief, QlearQuil All Day & Night, Tavist ND, Wal-itin.

Before taking loratadine – Precautions

• tell your doctor and pharmacist if you are allergic to loratadine, whatsoever other medications, or whatever of the ingredients in the type of loratadine y'all will exist taking. Check the package label for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products y'all are taking or plan to take. Be sure to mention medications for colds and allergies.
• tell your doctor if you lot have or accept ever had asthma or kidney or liver disease.
• tell your doctor if you lot are meaning, plan to become pregnant, or are breast-feeding. If you become meaning while taking loratadine, call your doctor.
• if you have phenylketonuria (PKU, an inherited status in which a special diet must be followed to prevent mental retardation), y'all should know that some brands of the orally disintegrating tablets may contain aspartame that forms phenylalanine.

What is fexofenadine used for

Fexofenadine is used to relieve the allergy symptoms of seasonal allergic rhinitis ("hay fever"), including runny olfactory organ; sneezing; cerise, itchy, or watery eyes (allergic conjunctivitis); itching of the nose, throat, or roof of the mouth in adults and children 2 years of age and older. Fexofenadine is too used to relieve symptoms of urticaria (hives; red, itchy raised areas of the skin), eczema including itching and rash in adults and children half-dozen months of historic period and older.

Fexofenadine is too used for reactions to insect bites, stings, some food allergies and a condition called chronic idiopathic urticaria in adults and children.

Fexofenadine is known equally a non-drowsy antihistamine. It'southward less likely to make you feel sleepy than some other antihistamines.

Fexofenadine dose

Usual Adult Dose for Allergic Rhinitis

180 mg orally once a twenty-four hour period OR sixty mg orally 2 times a 24-hour interval

Maximum dose: 180 mg/24-hour interval

Comment:

• Tablets should exist taken with water.

Uses:

• Relief of symptoms associated with seasonal allergic rhinitis (e.g., runny nose, sneezing, itchy, watery eyes, itching of the olfactory organ/throat)
• Treatment of uncomplicated pare manifestations of chronic idiopathic urticaria

Usual Adult Dose for Urticaria

180 mg orally once a day OR 60 mg orally 2 times a day

Maximum dose: 180 mg/day

Comment:

• Tablets should be taken with water.

Uses:

• Relief of symptoms associated with seasonal allergic rhinitis (e.g., runny nose, sneezing, itchy, watery optics, itching of the nose/pharynx)
• Treatment of uncomplicated peel manifestations of chronic idiopathic urticaria

Usual Pediatric Dose for Allergic Rhinitis

6 months to 2 years: fifteen mg orally 2 times a 24-hour interval

2 years to 11 years: thirty mg orally 2 times a mean solar day

12 years and older: 180 mg orally one time a day OR 60 mg orally 2 times a day

Comments:

• The oral interruption may be used by patients 6 months and older.
• Tablets and oral dissolving tablets may exist used past patients 6 to 11 years of age.
• Gel-coated tablet formulations should be limited to patients 12 years and older.

Uses:

• Relief of symptoms associated with seasonal allergic rhinitis (e.chiliad., runny olfactory organ, sneezing, itchy, watery eyes, itching of the nose/throat)
• Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Usual Pediatric Dose for Urticaria

half-dozen months to ii years: 15 mg orally 2 times a twenty-four hours

two years to xi years: 30 mg orally 2 times a day

12 years and older: 180 mg orally once a twenty-four hours OR 60 mg orally 2 times a solar day

Comments:

• The oral suspension may exist used past patients 6 months and older.
• Tablets and oral dissolving tablets may be used by patients 6 to 11 years of age.
• Gel-coated tablet formulations should be limited to patients 12 years and older.

Uses:

• Relief of symptoms associated with seasonal allergic rhinitis (due east.g., runny nose, sneezing, itchy, watery eyes, itching of the olfactory organ/throat)
• Treatment of uncomplicated pare manifestations of chronic idiopathic urticaria

Renal Dose Adjustments

Adult:

• Creatinine Clearance 90 mL/min or less: 60 mg orally in one case a day

Pediatric:

6 months to less than ii years:

• Creatinine Clearance 90 mL/min or less: 15 mg orally once a day

2 to eleven years:

• Creatinine Clearance 90 mL/min or less: 30 mg orally in one case a solar day

Liver Dose Adjustments

Data non available

Dialysis

Data not bachelor

How and when to have fexofenadine

If you or your kid take been prescribed fexofenadine, follow your doctor's instructions about how and when to take it.

How should fexofenadine be used?

Fexofenadine comes equally a tablet and a interruption (liquid) to accept by mouth. It is usually taken with water once or twice a day. Fexofenadine will work meliorate if information technology is non taken with fruit juices such as orangish, grapefruit, or apple juice. Take fexofenadine at around the same time(s) every twenty-four hours. Follow the directions on your prescription characterization carefully, and ask your medico or pharmacist to explain any office you do not sympathise. Have fexofenadine exactly as directed. Practise not have more than or less of it or take it more often than prescribed past your doctor.

Fexofenadine controls the symptoms of seasonal allergic rhinitis and urticaria but does not cure these conditions. Continue to take fexofenadine even if you feel well and are not experiencing these symptoms. If you wait likewise long between doses, your symptoms may go worse.

Shake the break well before each use to mix the medication evenly.

How much should I have?

Fexofenadine comes every bit tablets (30mg, 120mg and 180mg).

How much you have depends on why you're taking fexofenadine:

• For hay fever – the usual dose for adults and children aged 12 years and over is 120mg once a day. The usual dose for children anile half-dozen to 11 years is 30mg twice a day. In this instance, endeavor to space the doses 10 to 12 hours apart.
• For hives (nettle rash) – the usual dose for adults and children aged 12 years and over is 180mg one time a day.

Fexofenadine Dosing

The dose of this medicine will be unlike for different patients. Follow your doctor'south orders or the directions on the label. The following data includes only the average doses of this medicine. If your dose is different, do not change it unless your md tells you to do so.

The corporeality of medicine that yous take depends on the strength of the medicine. Also, the number of doses y'all take each day, the time allowed between doses, and the length of time yous accept the medicine depend on the medical problem for which you are using the medicine.

For symptoms of hay fever:

• For oral dosage class (capsules, tablets):
  • Adults and children 12 years of age and older—sixty milligrams (mg) ii times a mean solar day, or 180 mg once a day.
  • Children six to eleven years of age—xxx mg two times a day.
  • Children four to 6 years of age—Employ and dose must exist determined by your medico .
  • Children and infants upward to four years of age—Use is not recommended.
• For oral dosage grade (disintegrating tablets):
  • Children 6 to 11 years of age—30 milligrams (mg) ii times a day, on an empty tummy.
  • Children four to vi years of age—Use and dose must be determined by your medico .
  • Children and infants up to 4 years of historic period—Use is non recommended.
• For oral dosage form (suspension):
  • Children iv to 11 years of age—30 milligrams (mg) or 5 milliliters (mL) two times a day.
  • Children younger than four years of historic period—Apply and dose must exist determined by your doctor.

For symptoms of chronic hives:

• For oral dosage form (capsules, tablets):
  • Adults and children 12 years of age and older—sixty milligrams (mg) two times a solar day, or 180 mg in one case a day.
  • Children 4 to 11 years of age—30 mg two times a 24-hour interval.
  • Children younger than four years of age—Utilise and dose must exist determined past your doctor.
• For oral dosage course (disintegrating tablets):
  • Children four to xi years of age—30 milligrams (mg) two times a day, on an empty stomach.
  • Children younger than four years of age—Use and dose must be adamant past your doctor.
• For oral dosage form (suspension):
  • Children 4 to 11 years of age—30 milligrams (mg) or 5 milliliters (mL) two times a day.
  • Children 6 months to iv years of historic period—fifteen mg or 2.v mL two times a day.
  • Children younger than 6 months of age—Use and dose must be adamant by your doctor.

How to have fexofenadine

• If you're taking 30mg fexofenadine tablets, you tin take them with or without food.
• If you're taking 120mg and 180mg fexofenadine tablets, take them before a repast.

E'er accept your fexofenadine tablets with a drink of water. Swallow them whole – do not chew them.

Do Not accept fexofenadine with juice such as grapefruit, orange, or apple juice.

Y'all should Non have antacids that incorporate aluminum or magnesium hydroxide inside 15 minutes of taking this medicine. If you are uncertain about this, ask your doctor or pharmacist .

For patients using the oral disintegrating tablet form of fexofenadine:

• Brand sure your hands are dry.
• Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil bankroll and remove the tablet.
• Immediately place the tablet on top of the natural language. Do not chew or break the tablet.
• The tablet will deliquesce in seconds, and you may swallow it with your saliva. Yous may drink a drinking glass of water afterward the tablet has dissolved.
• Always take this tablet on an empty tummy.

Shake the oral liquid well before using it. Measure the liquid with a marked measuring spoon, oral syringe, or medicine cup.

When to take fexofenadine

Yous may simply need to take fexofenadine on a day yous have symptoms, such as if you lot've been exposed to something you're allergic to similar animal hair. Or you lot may need to accept information technology regularly to prevent symptoms, such every bit to finish hay fever during leap and summer.

What if I forget to take it?

If you lot're taking fexofenadine in one case a solar day, do not take a double dose to make upward for a forgotten dose. Take the side by side dose at the usual fourth dimension every bit prescribed by your dr..

If you forget doses often, it may help to gear up an warning to remind you lot. Yous could too enquire your pharmacist for advice on other ways to aid you recall to take your medicine.

What if I have too much fexofenadine?

Fexofenadine is generally very condom. Taking likewise much is unlikely to harm you.

If you lot take an actress dose by fault, you might become some of the common side effects. If this happens or you lot're concerned, contact your doctor.

Fexofenadine side effects

Like all medicines, fexofenadine can crusade side furnishings, although not everyone gets them.

Common side effects

Common side effects of fexofenadine happen in more i in 100 people. Talk to your physician or chemist if these side effects bother you or don't become abroad:

• feeling ill
• airsickness
• feeling sleepy
• headache
• dry mouth
• feeling empty-headed

Check with your health care professional if any of the post-obit side furnishings go along or are bothersome or if you have whatever questions about them.

Gastrointestinal

• Very common (10% or more than): Vomiting (upward to 12%)
• Common (1% to 10%): Nausea, diarrhea, stomach discomfort

Nervous system

• Very common (10% or more): Headache (up to 10.three%)
• Mutual (1% to 10%): Drowsiness, dizziness, somnolence

Other side effects

• Common (1% to 10%): Otitis media, pyrexia, fatigue, extremity pain

Respiratory

• Mutual (1% to 10%): Coughing, upper respiratory tract infection, rhinorrhea
• Frequency not reported: Dyspnea

Musculoskeletal

• Common (i% to x%): Back pain

Genitourinary

• Mutual (1% to 10%): Dysmenorrhea

Psychiatric

• Frequency non reported: Indisposition, nervousness, nightmares, sleep disorders or paroniria/excessive dreaming

Cardiovascular

• Frequency not reported: Palpitations, tachycardia, chest tightness

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions, angioedema, systemic anaphylaxis

Dermatologic

• Frequency not reported: Rash, pruritus, flushing

Less common side furnishings

• dorsum pain
• body aches or pain
• chills
• coughing
• diarrhea
• difficulty with moving
• dizziness
• ear congestion
• earache
• fever
• headache
• joint hurting
• loss of voice
• musculus aching or cramping
• muscle pains or stiffness
• nasal congestion
• nausea
• pain in arms or legs
• hurting or tenderness around eyes or cheekbones
• painful menstrual bleeding
• redness or swelling in ear
• ringing or buzzing in ears
• runny or stuffy nose
• sleepiness or unusual drowsiness
• sneezing
• sore throat
• stomach upset
• swollen joints
• unusual feeling of tiredness or weakness
• viral infection (such every bit cold and flu)

Other side effects not listed may likewise occur in some patients. If you observe any other effects, check with your healthcare professional.

Rare side furnishings

• Nervousness
• Rash
• Sleeplessness
• Terrifying dreams
• Problem sleeping
• Breast tightness
• Feeling of warmth, redness of the face, neck, arms and occasionally, upper breast
• Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• Shortness of breath, hard or labored animate

Although non all of these side effects may occur, if they do occur they may demand medical attention.

Bank check with your doc immediately if y'all have whatsoever of the side effects listed above.

Serious side effects

Information technology's rare to have a serious side consequence with fexofenadine.

• Tell your doc straight away if you accept a fast or irregular heartbeat.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction to fexofenadine.

• A serious allergic reaction is an emergency. Contact a physician straight away if you retrieve you or someone around you is having a serious allergic reaction.

The warning signs of a serious allergic reaction are:

• getting a peel rash that may include itchy, red, swollen, blistered or peeling peel
• wheezing
• tightness in the chest or throat
• having problem breathing or talking
• swelling of the mouth, face, lips, tongue, or throat

These are non all the side effects of fexofenadine. For a total listing see the leaflet within your medicines bundle.

How to cope with side furnishings

What to do about:

• feeling sick – stick to simple meals and don't eat rich or spicy food
• feeling sleepy – endeavour a unlike non-drowsy antihistamine. If this doesn't help, talk to your medico
• headache – take an everyday painkiller like paracetamol or ibuprofen
• dry out mouth – chew sugar-complimentary mucilage or suck sugar-free sweets
• feeling featherbrained – lie down until the dizziness passes, then go up slowly. Move slowly and carefully. Avoid java, cigarettes, booze and recreational drugs. If the dizziness doesn't get meliorate within a couple of days, speak to your pharmacist or doctor.

Man Toxicity Reports

Safety and efficacy of fexofenadine hydrochloride have non been established in children younger than vi years of historic period ^xiii) .

In clinical trials, dysmenorrhea occurred in one.5% of patients receivingoral fexofenadine 60 mg twice daily, compared to 0.iii% in patients receiving placebo ¹⁴⁾ .

In controlled clinical studies in patients 12 years of age and older with allergic rhinitis receiving oral fexofenadine hydrochloride dosages of 60 mg twice daily or placebo, drowsiness or fatigue occurred in 1.iii% of patients, compared with 0.9% of those receiving placebo ^fifteen) . In these studies in patients receiving fexofenadine hydrochloride dosages of 180 mg once daily (as conventional tablets) or placebo, headache was reported in 10.six or vii.5% of patients, respectively. In controlled studies in children half-dozen-11 years of age with seasonal allergic rhinitis receiving fexofenadine hydrochloride dosages of 30 mg twice daily or placebo, headache was reported in 7.2 or 6.six% of patients, respectively, while pain was reported in 2.4 or 0.4% of patients, respectively ^sixteen) .

During controlled clinical studies, nausea and dyspepsia were reported in 1.6 and one.3%, respectively, of patients receiving oral fexofenadine hydrochloride dosages of 60 mg twice daily versus 1.5 and 0.six%, respectively, of those receiving placebo ¹⁷⁾ .

Rash, urticaria, pruritus, and hypersensitivity reactions including angioedema, breast tightness, dyspnea, flushing, or anaphylaxis have been reported rarely in patients receiving fexofenadine hydrochloride ¹⁸⁾ .

In controlled studies in adults and children 12 years and older with chronic idiopathic urticaria receiving fexofenadine hydrochloride dosages of 60 mg twice daily or placebo, both back pain and sinusitis were reported in 2.ii or 1.ane% of patients, respectively ^nineteen) .

Clinical information from over 2000 patients signal that fexofenadine hydrochloride lacks the cardiotoxic potential of its parent drug terfenadine ²⁰⁾ . In 714 patients with seasonal allergic rhinitis, fexofenadine hydrochloride dosages of 60-240 mg twice daily were non associated with statistically significant hateful increases in the QT interval corrected for charge per unit (QTc) in controlled clinical studies. In add-on, in 231 healthy individuals, fexofenadine hydrochloride dosages of 240 mg given once daily for 1 year besides were not associated with statistically significant increases in the mean QTc. Even at dosages exceeding these (e.1000., up to 400 mg twice daily for half dozen days in twoscore patients, up to 690 mg twice daily for about 1 month in 32 patients, upwardly to 800 mg given in a single dose in 87 patients), statistically meaning mean increases in the QTc or other ECG abnormalities have not been reported in healthy adults or patients with seasonal allergic rhinitis ²¹⁾ .

Viral infection (eg, cold, influenza) or dysmenorrhea was reported in 2.5 or i.5% of patients 12 years of age and older receiving fexofenadine hydrochloride in dosages of 60 mg twice daily, respectively. In controlled clinical studies in adults and children 12 years of age and older receiving fexofenadine hydrochloride dosages of 180 mg once daily or placebo, upper respiratory tract infection was reported in 3.ii or 3.i% of patients, respectively, while back hurting was reported in two.8 or i.4% of patients, respectively ²²⁾ .

In controlled studies in children vi-11 years of historic period with seasonal allergic rhinitis receiving fexofenadine hydrochloride 30 mg twice daily, upper respiratory tract infection, coughing, accidental injury, fever, and otitis media occurred in 4.3, 3.8, 2.9, 2.iv, and 2.iv% of children, respectively, while these adverse furnishings were reported in 1.7, 1.3, 1.3, 0.9, and 0%, respectively, in those receiving placebo ²³⁾ .

To proceeds insight into possible mechanisms of and predisposing factors for torsades de pointes during terfenadine therapy, spontaneous reports in the US Nutrient and Drug Administration's Spontaneous Reporting System database were examined ²⁴⁾ . Based on the characteristics of the cases, in vitro cardiac electrophysiologic studies were conducted to test the hypothesis that terfenadine, and not its major metabolite, has actions similar to those of quinidine and is responsible for this form of cardiac toxicity. Spontaneous reports from the general medical customs. Every bit of Apr i, 1992, 25 cases of torsades de pointes had been reported to the Food and Drug Administration'south Spontaneous Reporting Organization. Predisposing factors in these cases indicated that the parent drug Terfenadine, but non its metabolite Fexofenadine, may accept actions similar those of quinidine that are responsible for inducing arrhythmia ²⁵⁾ . In vitro studies found that terfenadine is equipotent to quinidine as a blocker of the delayed rectifier potassium electric current in isolated feline myocytes. The metabolite, terfenadine carboxylate, did not inhibit this potassium current even at concentrations 30 times higher than the concentration of terfenadine producing a half-maximal effect. Since blockade of the potassium channel did not occur with the major metabolite of terfenadine, episodes of torsades de pointes are most probable the effect of a quinidine-like action of the parent drug and of factors that impair the normally rapid metabolism of terfenadine. Dosage restriction and awareness of the clinical atmospheric condition and drug interactions capable of inhibiting the metabolism of terfenadine are essential for prevention of this serious reaction ²⁶⁾ . In controlled trials with approximately 6,000 persons, no case of fexofenadine-associated torsades de pointes was observed. The frequency and magnitude of QTc outliers were like betwixt fexofenadine HCl and placebo in all studies. Based on a large clinical database, the authors conclude that fexofenadine HCl has no significant effect on QTc, even at doses > x-fold higher than that is efficacious for seasonal allergic rhinitis ²⁷⁾ .

Fexofenadine overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Data is also available online at https://www.poisonhelp.org/help. This is a free and confidential service. All local poisonous substance control centers in the United States use this national number. You should call if you have any questions most poisoning or poison prevention. Information technology does NOT need to be an emergency. You tin call for whatever reason, 24 hours a day, 7 days a week.

Fiddling data is available regarding toxicity. Clinical effects are anticipated to be an extension of adverse furnishings reported with therapeutic utilise. Dizziness, drowsiness, and dry mouth have been reported with fexofenadine overdose.

Symptoms of Allegra overdose may include:

• dizziness
• drowsiness
• dry oral cavity

References    [ + ]

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Source: https://healthjade.com/fexofenadine/

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